The development of tumor-on-chip technology is driven by a need to improve our understanding of cancer and develop more effective cancer treatments. Traditional methods for studying cancer involve growing cancer cells in 2D cell cultures or animal models, but these methods have several limitations. In 2D cell cultures, cancer cells often behave differently than they do in the complex 3D environment of tumors in the body. In animal models, the tumors may not accurately mimic human tumors, and the experiments can be time-consuming, expensive, and ethically challenging. Tumor-on-chip technology offers a promising alternative by allowing researchers to create microscale devices that replicate the 3D environment of tumors in the body, complete with blood vessels and other components of the tumor microenvironment. These chips can be used to study how tumors grow and spread, how they respond to different treatments, and how the surrounding tissues and immune system interact with the tumor. By using tumor-on-chip technology, researchers can gain a better understanding of cancer biology and develop more effective cancer treatments. Tumor-on-chip technology also has the potential to reduce the reliance on animal models and improve the efficiency and cost-effectiveness of cancer research.